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. 2018 Jan 4;8:949. doi: 10.3389/fphar.2017.00949

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Copyright © 2018 Fiore, Ramesh, Proto, Piscopo, Franceschelli, Anzelmo, Medema, Bifulco and Gazzerro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) MTT assay performed in HCT116 cells treated with indicated concentrations of Rimonabant (μM) or 5FU (μM) alone or in combination; data are expressed as means ± SD of 3 independent experiments performed in triplicate and reported as ratio vs. the vehicle control (^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001 vs. control). (B) Representative dose-effect curve performed at least twice in triplicate with CompuSyn software and showing the dose of the drug vs. the fraction of cells affected/killed (Fa) by Rimonabant (SR) or 5FU used alone or combined at constant molar ratio 1:2.5. (C) Combination Index plot (Fa-CI plot) computed by Compusyn software from the affected fraction (Fa) obtained at each dose of the drugs used in combination, at constant molar ratio 1:2.5. Representative experiment (carried out at least twice) is reported.