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. 2018 Jan 4;8:948. doi: 10.3389/fphar.2017.00948

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Copyright © 2018 Wu, Song, Hu and Dai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Paeonol treatment prevents VSMC proliferation and DNA synthesis by ox-LDL stimulation. (A) Effect of different concentrations of ox-LDL on VSMCs proliferation, as assessed by a CCK8 assay. (B) VSMCs were treated with the indicated concentration of Paeonol (7.5–240 μM) for 24 h in the absence or presence of ox-LDL (50 μg/mL). Cell viability was examined with CCK8 assay. (C) Cell proliferation was detected by BrdU assay. Data are the mean ± SD, n = 3. ^∗p < 0.05, ^∗∗p < 0.01 vs. control group. ^#p < 0.05, ^##p < 0.01 vs. ox-LDL group.