Table 5.
Concordance between microbiological culture growth results from BALF and NPS specimens in participants with any bacterial load and with bacterial loads meeting the cut-off for infection
| Isolates with any bacterial load, n (%) | Isolates with a bacterial load meeting the cut-off for infectiona, n (%) | |||||
|---|---|---|---|---|---|---|
| S. pneumoniae N = 49 |
H. influenzae
N = 71 |
M. catarrhalis
N = 82 |
S. pneumoniae
N = 30 |
H. influenzae
N = 15 |
M. catarrhalis
N = 18 |
|
| BALF | 49 (100%) | 71 (100%) | 82 (100%) | 20 (66.7%) | 12 (80.0%) | 11 (61.1%) |
| NPS | 49 (100%) | 71 (100%) | 82 (100%) | 18 (60.0%) | 6 (40.0%) | 10 (55.6%) |
| Both BALF and NPS | 49 (100%) | 71 (100%) | 82 (100%) | 8 (26.7%) | 3 (20.0%) | 3 (16.7%) |
| Concordance | 25 (51.0%) | 37 (52.1%) | 18 (22%) | 2 (6.7%) | 2 (13.3%) | 1 (5.6%) |
N, number of unique isolates; n (%), number (percentage) of unique isolates present in each specimen type; BALF, bronchoalveolar lavage fluid; NPS, nasopharyngeal swab; CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value
aBacterial load > 104 CFU/mL if the pathogen was present alone or > 105 CFU/mL if present as co-infection