Figure 6.

The hepatoprotective effect of osthole was mediated by its antioxidative property. (A, B) BSO (1 g/kg) was intraperitoneally administered to mice 1 h prior to APAP treatment on the fourth day. Serum ALT and AST levels at 6 h post-APAP were determined. (C, D) The mRNA levels of genes involved in inflammation and metabolism of APAP in the liver were quantified using real-time PCR at 6 h post-APAP. Data are expressed as the mean±SEM. n=4–7 mice per group. ^**P<0.01 compared to vehicle or control. ^##P<0.01 compared to APAP. ^§P<0.05, ^§§P<0.01 compared to APAP plus osthole.