Figure 5.

The average distance distributions between the activation switch residues W^6.48 and Y^7.43 in the five systems (A) and evolutions of these average distances in the BU72, TRV130 and NTX systems (B). (C) Detailed evolutions of the minimum distances between residue H^6.52 and water W1 in the BU72 system. (D, E) The distributions of the side chain torsion of “switching” residue W^6.48 in the five systems. (F) The distributions of the side chain torsion of important residue Y^7.43 in the four ligand-bound systems.