Table 1. Systems prepared for the MD simulations.

System ID	μ-OR state	Ligand	POPC	Na+	Cl−	Water
A	Active	BU72	106	51	65	11033
B	Active	TRV130	106	51	65	11032
C	Active	NTX	106	51	65	11030
D	Active	-	106	51	64	11039
E	Inactive	β-FNA	104	52	66	11001