Histopathological changes in the renal tissues and the renal tubular injury scores among the sham, IR, IR+V, IR+U, IR+U+W, IR+N+U and IR+W groups. (A) PAS staining images of histopathological changes in renal tissues among 7 groups (200×); (B) Renal tubular injury score among 7 groups. *P<0.05 vs the sham group. #P<0.05 vs the IR group. $P<0.05 vs the IR+U group. PAS, Periodic acid-Schiff; IR, ischemic reperfusion; V, normal saline; N, KOR antagonist Nor-BNI; U, KOR agonist U50448H; W, PI3K inhibitors wortmannin.