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. 2018 Jan 8;8:93. doi: 10.1038/s41598-017-18551-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Knockdown of Sema4B reduces tumor formation in vivo using a xenograft model. (A–D) Two groups of U87-MG cells were infected with either shRNA lentivirus targeting Sema4B or control and selected for three days before the beginning of the experiment. Each group of cells was injected subcutaneously into nude mice. (A) Macroscopic appearance of xenografts at the end of treatment. (B) Section of xenografts stained with hematoxylin/eosin. Scale bar 100 μm. (C) Change of tumor volume during treatment period. (D) Tumor weight at the end of the treatment. Data represent the means of n = 5 ± s.e.m. The p values were calculated after the data were confirmed to fulfill the criteria with Mann–Whitney U Test: p < 0.005.