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. 2018 Jan 8;8:58. doi: 10.1038/s41598-017-18255-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Clinical outcomes after initial intravitreal aflibercept (IVA) injections for patients with age-related macular degeneration exhibiting a good BCVA at baseline. (a–g) The mean logMAR BCVA (a), CVA (b), FVA (c), CRT (d), CCT (e), MV (f), and choroidal area (g) values at each time point after initial IVA treatment are plotted. (h) The proportion of eyes with a dry macula without exudative changes over the retinal pigment epithelium is 80%, 66% and 71% at 2, 6 and 12 months after initial IVA injections, respectively. The dry macula is shown in gray. BCVA, best-corrected visual acuity; CVA, contrast VA; FVA, functional visual acuity; CRT, central retinal thickness; CCT, central choroidal thickness; MV, macular volume. Data are shown as mean ± standard deviation. *P < 0.05, **P < 0.01.