Table 4.

Correlation between reduction in retinal values and improvement of visual function

	BCVA		Contrast VA		FVA score		VFQ-25 score
Month 6	r	P-value	r	P-value	r	P-value	r	P-value
CRT (μm)	0.264	0.664	0.497	0.029*	0.242	0.856	−0.577	0.013*
MV (mm3)
Whole Layer (ILM-BM)	0.381	0.164	0.637	0.001**	0.559	0.008**	−0.251	0.944
Inner Layer (ILM-INL)	0.200	0.999	0.545	0.011*	0.524	0.017*	−0.222	0.999
Outer Layer (OPL-BM)	0.479	0.032*	0.611	0.002**	0.558	0.008**	−0.163	0.999
Month 12
CRT (μm)	0.256	0.752	0.265	0.728	0.118	0.999	−0.660	0.004**
MV (mm3)
Whole Layer (ILM-BM)	0.310	0.440	0.562	0.009**	0.544	0.013*	−0.507	0.064
Inner Layer (ILM-INL)	0.163	0.999	0.564	0.009**	0.424	0.110	−0.363	0.388
Outer Layer (OPL-BM)	0.384	0.176	0.499	0.032*	0.474	0.049*	−0.448	0.152

Spearman’s test with Bonferroni correction was performed. Correlation between reduction in retinal layer volumes at month 6 and 12 from baseline values, and improvement of visual function at respective time point was analyzed. BCVA, best-corrected visual acuity; FVA, functional visual acuity; VFQ, visual function questionnaire; CRT, central retinal thickness; MV, macular volume; RPE, retinal pigment epithelium; BM, Bruch’s membrane. *P < 0.05, **p < 0.01.