Table 1.

Representative features used to train Hridaya.

Feature type	Representative features
Transcriptomic	• Differential gene expression (and its absolute value) between DCM and normal individual heart samples.• Median gene expression of DCM and normal individuals (MAGNet, http://www.med.upenn.edu/magnet/, GSE57338).• The number of tissues, based on GTEx data^13,14, for which gene expression is significantly more (or less) than gene expression of the gene in the left ventricle (LV) and LV-tissue specific expression rank (LV-tissue specific features).
Transcriptomic and Phenotypic	• Correlation of gene expression with various phenotypes of the individuals in MAGNet data.
Genetic	• GWAS (Genome-wide association studies) signal of eQTL SNPs of the gene.
Evolutionary	• Phylogenetic profile of the gene with 65 species¹⁷.• Residual variation intolerance score (RVIS)¹⁶.• D_N/D_S ratio between human and mouse¹⁷.
Epigenetic	• Signals of various histone marks, transcription factors from Left/Right Ventricle, Aorta, Fetal Heart^11,12.• p300 transcription factor signal (GSM807734¹⁵) around transcription start site of the gene from the adult heart (p300 is often seen as an enhancer mark^68,69).• DNase hypersensitivity data around the gene transcription start site^11,12.

The detailed list of 181 features are provided in Supplementary Table S1.