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. 2018 Jan 8;8:102. doi: 10.1038/s41598-017-18260-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Liver dysfunction induced by excessive sFlt1 in mice lacking eNOS. (a) Liver weight (Wt). (b) Liver Wt/body weight (BW). Excessive sFlt1 causes hepatomegaly. The levels of plasma Aspartate transaminase (AST) and Alanine transaminase (ALT) are severely increased in eNOS ^−/−; sFlt1 mice (c,d) n = 7–9. Data are shown as mean ± s.e.m. ANOVA or Kruskal-Wallis test.