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. 2018 Jan 8;9:100. doi: 10.1038/s41467-017-02601-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — HoxC5 inhibits hTERT expression. a A schematic representation of mir-615-3p genomic localization in the intron of HOXC5. b, c Relative hTERT mRNA expression and telomerase activity in HeLa, PC-3, U251, or BT549 cells transduced with lentivirus overexpressing Flag-tagged HOXC5. The telomerase activity in cells transiently transfected with control GFP vector is set as (1). d Telomere length in HeLa, PC-3, U251, or BT549 cells transduced with lentivirus overexpressing GFP or Flag-tagged HOXC5. PD: population doubling. e The expression of endogenous HOXC5 mRNA in HeLa cells expressing control shRNA or two independent anti-HOXC5 shRNAs. f Relative hTERT mRNA expression in HeLa cells expressing control shRNA or two independent anti-HOXC5 shRNAs. g Telomere length in HeLa cells transduced with lentivirus overexpressing control shRNA or two independent anti-HOXC5 shRNAs. Significance was determined by t test. *P < 0.05. PD population doubling