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. 2018 Jan 8;8:38. doi: 10.1038/s41598-017-18635-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Experimental time course. At day -28 tumor cells were injected into the dorsal skin. DSWC was implanted after the tumor volume reached 3–5 mm in diameter. Tumors were irradiated ~10 days after DSWC installation (day 0 labeled with “R”). Right after irradiation tumor vasculature was monitored within 90 minutes (minutes time scale). For five to eight weeks following irradiation, tumor changes were monitored repeatedly with caliper measurements (tumor volume), svOCT imaging (vasculature) and epi-fluorescence microscope imaging (cancer cell fluorescence). Tumor resection for histological staining was performed at selected post-RT stages in several animals to support and validate the in-vivo observations. White light images of the (b) back and (c) front of the tumor within window chamber. (d) svOCT microvasculature map of the area labeled with black dotted rectangle in (c). (e) Tumor cells Ds-Red fluorescence image. Scale bars are 500 μm.