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. 2018 Jan 8;8:87. doi: 10.1038/s41598-017-18035-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pre- and post-contrast ADC measurements in three illustrative lesions. The lesions were first localized using T1-weighted, T2-weighted and dynamic contrast enhanced (DCE) images (DCE images shown in the left column). A whole lesion covering region of interest (ROI) was drawn on the pre-contrast b = 800 s/mm² image. This ROI was then replicated on pre- and post-contrast ADC maps. Images in the right column show ROIs on the pre- and post-contrast ADC maps that were generated using the b values of 0, 200, 400, 600, and 800 s/mm². (A) A large ductal carcinoma of 47 mm in diameter in the right breast. (B) A ductolobular carcinoma of 21 mm in diameter in the left breast. (C) An intraductal papilloma (red arrow) of 13 mm in diameter in the right breast. A circumscribed, oval hemorrhagic cyst (blue arrow) was detected lateral to the enhancing mass.