Table 4.
Review of the literature about the effects of contrast agents on apparent diffusion coefficient (ADC) values in breast tumors.
| Number of patients (N of lesions) | Rubesova et al.16 | Yuen et al.17 | Janka R et al.18 | Nguyen et al. (2016) | Present study |
|---|---|---|---|---|---|
| 5 (7; 2 benign, 5 malignant) | 19 (19; 19 malignant) | n/a (35; 10 benign, 25 malignant) | 19 (19; 19 malignant of which 14 mass-like enhancing and 5 NMLE lesions) | 27 (32; 7 benign, 25 malignant, all lesions mass-like enhancing lesions) | |
| MRI field strength, vendor, manufacturer | 1.5 T, Magnetom Symphony, Siemens | 1.5 T, Gyroscan Intera Nova Dual, Philips | 1.5 T, Magnetom Avanto, Siemens | 3.0 T, Achieva Tx, Philips | Achieva TX, Philips, Achieva Tx, Philips |
| b value combinations | n/a | ADC0,1000 | ADC50,400,800 | ADC0,100,800; ADC0,800; ADC100,800 | ADC0,200,400,600,800; ADC400, 600,800; ADC0,200,400; ADC0,200,800; ADC0,400,800; ADC0,200; ADC0,800; ADC200,800 |
| Contrast agent (dose mmol/kg) | Gadodiamide (0.3) | Gadopentetate dimeglumine (0.1) | Gadobutrol (0.1) | Gadoteridol (0.1) | Gadoterate meglumine (0.2) |
| DCE-MRI acquisition time (minutes) | 15 | 8 | 6 | 9 | 6 |
| Median TR/TE (ms) | 2600/110 | 1206/71 | 4100/98 | 5336/61 | 6982/95 |
| Mean ± SD pre-contrast/post-contrast ADC values mm2/s (P) | n/a (ns.) | 1.35 ± 0.38/1.04 ± 0.34 (P = 0.01) | Benign lesions: 1.99 ± 0.37/1.97 ± 0.30 (P = ns.). Malignant lesions: 0.90 ± 0.14/0.80 ± 0.14 (P < 0.01) | ADC0,100,800: 1.10/1.10 (P = ns.)a ADC0,800: 1.14/1.09 (P = ns.)a A ADC100,800: 0.92/0.87 (P = ns.)a | All lesions ADC0,200,400,600,800: 1.05 ± 0.35/1.03 ± 0.36 (P = 0.042). Other b value combinations: no significant differences in ADC values (P = ns.). Malignant lesions: ADC0,200,400,600,800: 0.93 ± 0.28/0.92 ± 0.28 (P = 0.042); ADC0,200,400: 0.92 ± 0.28/0.90 ± 0.27 (P = 0.040). Other b value combinations: no significant differences in ADC values (P = ns.). Benign lesions: No significant differences in ADC values (P = ns.). |
N = number; n/a = not applicable information; ns. = not significant; TR = repetition time; TE = echo time; DCE-MRI = dynamic contrast enhanced magnetic resonance imaging.
aInstead of mean pre- and post-G-CA ADC values, the authors report median values.