Table 1. List of the 58 high-confidence sites.
| miRNA | Locus | Maximal editing levels | Tissue type | In seed? | Validated by miRgene? |
|---|---|---|---|---|---|
| hsa-let-7c | 27 | 27.4 | LAML Tumor | No | Yes |
| hsa-let-7d | 66 | 0.8 | LUSC Normal | Yes | Yes |
| hsa-let-7e | 57 | 1.7 | PCPG Tumor | Yes | Yes |
| hsa-mir-1251 | 10 | 28.6 | GBM Normal | Yes | Yes |
| hsa-mir-1260b | 18 | 100.0 | GBM Normal | No | No |
| hsa-mir-1301 | 52 | 4.5 | GBM Normal | Yes | Yes |
| hsa-mir-1304 | 57 | 17.9 | GBM Normal | Yes | No |
| hsa-mir-130b | 71 | 4.6 | PCPG Normal | No | Yes |
| hsa-mir-151a | 49 | 7.8 | GBM Normal | Yes | Yes |
| hsa-mir-200b | 61 | 6.3 | PCPG Normal | Yes | Yes |
| hsa-mir-24–2 | 18 | 5.0 | LUAD Normal | Yes | Yes |
| hsa-mir-27a | 10 | 3.8 | PCPG Tumor | No | Yes |
| hsa-mir-27a | 56 | 1.4 | PCPG Tumor | Yes | Yes |
| hsa-mir-301a | 70 | 3.4 | LUAD Normal | No | Yes |
| hsa-mir-301b | 64 | 35.7 | GBM Normal | No | Yes |
| hsa-mir-3157 | 70 | 34.5 | BLCA Normal | No | No |
| hsa-mir-3167 | 62 | 25.0 | LUAD Tumor | No | No |
| hsa-mir-337 | 66 | 6.3 | GBM Normal | Yes | Yes |
| hsa-mir-3622a | 52 | 60.3 | GBM Normal | Yes | Yes |
| hsa-mir-3681 | 10 | 9.6 | LIHC Tumor | Yes | Yes |
| hsa-mir-376a-1 | 9 | 42.9 | UVM Tumor | Yes | Yes |
| hsa-mir-376a-1 | 49 | 90.0 | THCA Normal | Yes | Yes |
| hsa-mir-376a-2 | 15 | 69.2 | LUAD Normal | Yes | Yes |
| hsa-mir-376a-2 | 55 | 89.4 | PRAD Normal | Yes | Yes |
| hsa-mir-376b | 67 | 3.6 | PAAD Normal | Yes | Yes |
| hsa-mir-376c | 48 | 44.8 | PCPG Tumor | Yes | Yes |
| hsa-mir-377 | 54 | 7.5 | GBM Normal | No | Yes |
| hsa-mir-378a | 58 | 32.2 | BLCA Normal | No | Yes |
| hsa-mir-378b | 53 | 100.0 | LAML Tumor | No | No |
| hsa-mir-378c | 31 | 12.8 | OV Tumor | No | No |
| hsa-mir-379 | 10 | 8.1 | GBM Normal | Yes | Yes |
| hsa-mir-381 | 52 | 61.8 | PCPG Tumor | Yes | Yes |
| hsa-mir-381 | 55 | 1.5 | PCPG Tumor | Yes | Yes |
| hsa-mir-411 | 20 | 53.6 | GBM Normal | Yes | Yes |
| hsa-mir-421 | 54 | 3.6 | PCPG Tumor | Yes | Yes |
| hsa-mir-421 | 61 | 7.6 | PCPG Tumor | No | Yes |
| hsa-mir-4510 | 20 | 100.0 | PCPG Normal | No | No |
| hsa-mir-455 | 32 | 9.1 | LUAD Normal | No | Yes |
| hsa-mir-4662a | 8 | 6.7 | LUSC Normal | Yes | Yes |
| hsa-mir-488 | 56 | 4.9 | PCPG Tumor | Yes | Yes |
| hsa-mir-497 | 25 | 17.4 | LUAD Normal | Yes | Yes |
| hsa-mir-497 | 83 | 71.5 | LUSC Normal | No | Yes |
| hsa-mir-503 | 7 | 7.8 | BLCA Normal | Yes | Yes |
| hsa-mir-532 | 34 | 0.6 | PCPG Tumor | No | Yes |
| hsa-mir-539 | 18 | 16.2 | LUAD Normal | No | Yes |
| hsa-mir-556 | 60 | 30.3 | PCPG Tumor | Yes | Yes |
| hsa-mir-561 | 69 | 38.2 | READ Tumor | No | Yes |
| hsa-mir-589 | 66 | 93.9 | PCPG Tumor | Yes | Yes |
| hsa-mir-598 | 62 | 1.0 | PCPG Tumor | Yes | No |
| hsa-mir-605 | 54 | 83.3 | COAD Tumor | Yes | Yes |
| hsa-mir-624 | 58 | 39.3 | LIHC Normal | Yes | Yes |
| hsa-mir-625 | 58 | 16.9 | KICH Normal | Yes | Yes |
| hsa-mir-6503 | 59 | 67.8 | LIHC Normal | Yes | No |
| hsa-mir-664a | 18 | 11.3 | GBM Normal | No | No |
| hsa-mir-944 | 59 | 7.5 | KICH Normal | Yes | Yes |
| hsa-mir-98 | 32 | 55.6 | READ Normal | No | Yes |
| hsa-mir-99a | 13 | 12.4 | LUAD Normal | No | Yes |
| hsa-mir-99b | 47 | 1.3 | PCPG Tumor | Yes | Yes |
Sites with at least one tissue type with >1% editing levels were kept for further analyses. miRNA annotations are based on miRBase db, location represents the position of the editing site within the pre-microRNA. The reported maximal editing levels represents the highest (weighted average) editing level across the 55 tissues studied. See Supplementary Table S1 for tissues acronyms.