Table 4. Types of insertions observed in control and Pol β-depleted cells.
Type of insertion signature | Control # (%)5 | siPOLB # (%)5 | P-value6 |
---|---|---|---|
Templated insertions1 | 4297 (49.3) | 2487 (56.2) | 4.70 × 10−11 |
Templated slippage2 | 55 (0.63) | 114 (2.6) | 2.18 × 10−18 |
Misincorporation and synthesis across break3 | 108 (1.2) | 13 (0.29) | 5.46 × 10−5 |
Complex insertions templating from the TetR4 | 7 (0.080) | 37 (0.8) | 1.723 × 10−9 |
1Templated insertions.
2Templated slippage.
3Misincorporation and synthesis across break.
4Complex insertions templating from TetR.
5([Number of insertion sequences in each type of insertion signature/Total # of insertion sequences] × 100).
6Chi-square test P-values adjusted with the Bonferroni correction.