Figure 2.

Snail1 regulates telomere length in MSC. (A) Representative metaphase spreads at late passages (PD 146) of Snail1 control MSC (CT) or Snail1 KO MSC. Telomeres were stained with a Cy3-labeled PNA telomere probe. (B) Q-FISH analysis showing the distribution of telomere fluorescent intensity in metaphase chromosomes from MSC. Data were accumulated using 40 metaphases for each histogram. Telomere intensity is expressed with arbitrary units; the average is indicated for each histogram. (C) Quantification of (B) from three independent Q-FISH analyses. *P < 0.05.