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. 2017 Sep 4;37(1):8–17. doi: 10.1038/onc.2017.306

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Overall structure of RCC2 and the structural elements accounting for interaction with Rac1. (a) Ribbon diagram of the RCC2 propeller structure viewed along or perpendicular to the central shaft. The blades are numbered (1–7) along the sequence. (b) Superimposition of human RCC2 (cyan) and human RCC1 (gray) structures viewed perpendicular to or along the central shaft. The extra structural elements in RCC2 (loop 1, loop 2 and β-hairpin) relative to RCC1 are shown in magenta. The extra β-wedge required for RCC1 guanine exchange factor activity is shown in yellow. (c) RCC2 deletion mutants used in this study. (d) S-tag-HA-tag RCC2 mutants were expressed in vivo and lysates were incubated with purified His-Rac1 protein. Rac1 or RCC2 was then evaluated with anti-Rac1 or anti-HA antibody respectively. See also Supplementary Figure S4.