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. 2017 Sep 11;37(1):128–138. doi: 10.1038/onc.2017.316

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Copyright © 2018 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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EGR1 mediates the expression of TGF-β1 induced by oncogenic KRAS. (a) Oncogenic KRAS upregulated TGF-β1 expression and this was inhibited by MEK inhibitor U0126. (b) KRAS-induced EGR1 expression. MEK inhibitor U0126 suppressed the induction. (c) Induction of TGFb1 by oncogenic KRAS relies on EGR1-binding site in promoter as shown by luciferase reporter assay. The value is presented as the mean±s.e.m. ** P<0.01, ***P<0.001.