Skip to main content
. Author manuscript; available in PMC: 2018 Jan 9.
Published in final edited form as: Toxicol Appl Pharmacol. 2017 Feb 11;320:26–31. doi: 10.1016/j.taap.2017.02.009

Fig. 4.

Fig. 4

Inhibition of ER stress or oxidative stress protects iCell Neurons against TD-induced cell death. A. The cultured iCell Neurons were pretreated with STF083010 (10 μM), Salubrinal (10 μM), or NAC (1 mM) for 1 h, and followed by exposure to 1 mM amprolium in the continued presence of STF083010, Salubrinal, or NAC for 5 days. The viability of cells was determined by CCK-8. The experiment was replicated three times, and the results were expressed as the mean ± SEM. *p < 0.05, statistically significant difference from untreated control groups. #p < 0.05, statistically significant difference from amprolium alone groups. B. The cultured iCell neurons were pretreated with STF083010 (0 or 10 μM) or NAC (0 or 1 mM) for 1 h, and followed by exposure to 1 mM amprolium in the presence or absence of STF083010 or NAC for 5 days. The neurons were stained with calcein AM and examined under the microscope. Bar = 20 μm.