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. 2017 Nov;38(3):131–142.

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The contents of articles or advertisements in The Clinical Biochemist – Reviews are not to be construed as official statements, evaluations or endorsements by the AACB, its official bodies or its agents. Statements of opinion in AACB publications are those of the contributors. Print Post Approved - PP255003/01665. Copyright © 2005 The Australasian Association of Clinical Biochemists Inc. No literary matter in The Clinical Biochemist – Reviews is to be reproduced, stored in a retrieval system or transmitted in any form by electronic or mechanical means, photocopying or recording, without permission. Requests to do so should be addressed to the Editor. ISSN 0159 – 8090

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Crystal structure complex of the Xenopus Wnt8 with the mouse Fzd8 cysteine-rich domain (PDB 4F0A). The N-terminal domain (blue) contains the Wnt ‘thumb’, featuring lipid modification and is bound by a site generally conserved among Frizzled cysteine-rich domains. The C-terminal domain (red) contains the Wnt ‘index finger’, a moderately conserved, cysteine-rich, two-stranded β-sheet, which is bound by a site on the opposite face of Frizzled cysteine-rich domains to that bound by the thumb.