Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Nov;38(3):131–142.

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

The contents of articles or advertisements in The Clinical Biochemist – Reviews are not to be construed as official statements, evaluations or endorsements by the AACB, its official bodies or its agents. Statements of opinion in AACB publications are those of the contributors. Print Post Approved - PP255003/01665. Copyright © 2005 The Australasian Association of Clinical Biochemists Inc. No literary matter in The Clinical Biochemist – Reviews is to be reproduced, stored in a retrieval system or transmitted in any form by electronic or mechanical means, photocopying or recording, without permission. Requests to do so should be addressed to the Editor. ISSN 0159 – 8090

PMC Copyright notice

Wnt7/FZD4/GRP124/LRP5 signalling cascade. Activation of canonical Wnt/β-catenin signalling is initiated through Wnt7a/b binding to Fzd4. GPR124 and LRP5 act as co-receptors through which signal transduction is conveyed to destabilise the destruction complex (Axin, GSK3β, CK1α/ɛ). β-catenin is stabilised, allowing its translocation to the nucleus, where it can bind to TCF/LEF transcription factors, leading to vascularisation and angiogenesis.