Table 2.
Risk factors of HBV reactivation in HBsAg-positive patients with hematological malignancy
| Factors | Reactivation N = 97 |
No Reactivation N = 189 |
Univariate P value |
Multivariate P Value |
Odds ratio(95% CI) |
|---|---|---|---|---|---|
| Hematological malignancy | 0.332 | NA | |||
| AML | 29 | 46 | |||
| ALL | 3 | 10 | |||
| Lymphoma | 46 | 96 | |||
| CML/MPN | 1 | 5 | |||
| CLL | 2 | 3 | |||
| Myeloma | 10 | 21 | |||
| MDS/AA | 6 | 8 | |||
| Age > 65 year | 0.052 | 0.198 | |||
| Yes | 11 | 57 | |||
| No | 86 | 132 | |||
| Gender | 0.781 | NA | |||
| Man | 55 | 106 | |||
| Woman | 42 | 83 | |||
| Hepatitis C | 0.180 | 0.453 | |||
| Yes | 4 | 4 | |||
| No | 93 | 185 | |||
| Liver cirrhosis | 0.906 | NA | |||
| Yes | 4 | 7 | |||
| No | 93 | 182 | |||
| Hepatocellular carcinoma | 0.032 | <0.001 | 0.101(0.029–0.355) | ||
| Yes | 3 | 1 | |||
| No | 94 | 188 | |||
| Diabetes mellitus | 0.388 | NA | |||
| Yes | 10 | 20 | |||
| No | 87 | 169 | |||
| Allogeneic transplantation | 0.113 | 0.269 | |||
| Yes | 28 | 31 | |||
| No | 69 | 158 | |||
| Antiviral prophylaxis | <0.001 | <0.001 | 4.631(2.902–7.390) | ||
| Yes | 26 | 145 | |||
| No | 71 | 44 |
AML acute myeloid leukemia, ALL acute lymphoblastic leukemia, CML/MPN chronic myeloid leukemia/myeloproliferative neoplasm, CLL chronic lymphocytic leukemia, MM myeloma, MDS/AA myelodysplastic syndrome/aplastic anemia