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. 2018 Jan 8;19:28. doi: 10.1186/s12864-017-4409-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Age-dependent changes in A-to-I RNA editing and gene expression in rat brain. a Significant age-dependent changes in RNA editing at non-synonymous editing sites in PFC (a₁) and AMY (a₂). b Age-dependent changes in Adar and Adarb1 mRNA expression in PFC (b₁) and AMY (b₂). c Age-dependent changes in Htr2c A-D site editing (c₁) and mRNA expression (c₂) in PFC. d Age-dependent changes in Htr2c A-D site editing (d₁) and mRNA expression (d₂) in AMY. e Age-dependent changes in Htr2c isoform prevalence in PFC (e₁) and AMY (e₂). Columns represent individual samples. Rows represent editing sites. *p < 0.05, **p < 0.001, # < 0.075, white, significance in PFC; gray, significance in AMY. N’s, RNA editing; P0 5, P60 5; Gene expression (Adar/b1), PFC: 12, 5; AMY: 9, 5; Htr2c, 11, 5; 5, 9