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. 2018 Jan 9;15:1. doi: 10.1186/s12976-017-0073-6

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — A lumped compartmental model of blood and thyroid gland. We assume Methimazole (MMI) dynamics in the blood serum is similar to MMI dynamics in the functional thyroid gland. The release of thyroxine (T4) depends on the stimulation of TRAb and inhibition of MMI in the functional gland