Table 2.

Parameter Estimates, Description, Units and Source

Parameter	Description	Value	Source	Units
k 1	Relative maximum uptake rate of MMI	8.374×10−3	Literature [28]	mg/(mL∗Lday)
k 2	Elimination rate of MMI	3.3271	Estimated	1/day
k a	Michealis-Menten constant for half maximal uptake rate of MMI	0.358068	Simulation	mg/L
k 3	Relative maximum secretion rate of FT4	0.119	Calculation	pg/(mL2day)
k d	Michealis-Menten constant for half maximal secretion rate of FT4	0.05	Simulation	U/mL
k 4	Elimination rate of FT4	0.099021	Estimated	1/day
k 5	Relative growth rate of the functional size of thyroid gland	1×106	Simulation	mL3/(U∗day)
N	Maximal growth ratio	0.833	Calculation	U/(mL2)
k 6	Thyroid inactivation rate constant	0.001	Simulation	mL/mg∗day
k 7	Maximal production rate of TRAb	0.875	Calculation	U/(mL∗day)
k b	Inhibition rate of TRAb	1.5	Simulation	mg/L
k 8	Elimination rate of TRAb	0.035	Estimated	1/day