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. Author manuscript; available in PMC: 2018 Jan 9.
Published in final edited form as: Neuroscience. 2017 Feb 8;348:63–72. doi: 10.1016/j.neuroscience.2017.01.050

Fig. 4.

Fig. 4

Raw and integrated (∫) recordings of abdominal (AbN), cervical vagus (cVN) and phrenic nerve (PN) activities of an in situ preparation, representative of the group, showing the increase in breathing frequency upon peripheral chemoreflex activation (with KCN, arrows) before and after the inhibition of the KF with bilateral microinjections of isoguvacine (10 mM, ISO arrow). Representative traces of the reduced tachypnea observed in 7 rats upon KCN stimulation after kF inhibition (A) and the bradypnea observed in 6 rats upon KCN stimulation after KF inhibition (B) are both shown. Average values are presented for PN burst frequency under basal conditions and after stimulation with KCN observed before KF inhibition and after KF inhibition (C), and for the percentage changes (relative to baseline) in PN burst amplitude (D), inspiratory and post-inspiratory (post-I) cVN activities (E) and AbN amplitude (F) after KCN before and after KF inhibition. Bars represent means ± S.E.M. n = 13, * represents p < 0.05.