Table 1. Genome-wide survival analysis of Alzheimer’s Disease.

(a) Description of Consortia samples with available phenotype and genotype data included in the genome-wide survival analysis. AAO: age at onset. AAE: age at last examination. (b) Summary of loci with significant (P < 5×10⁻⁸) or suggestive (P < 1×10⁻⁵) associations from the genome-wide survival analysis.

a
		Cases			Controls
Dataset	N	Percent women	Mean AAO yrs (s.d.)	N	Percent women	Mean AAE yrs (s.d.)
ADGC	8617	58.9	74.2 (8.1)	9765	60.1	77.1 (8.4)
GERAD	2615	63.4	73.0 (8.5)	1148	62.1	76.5 (7.0)
EADI case-control study	1420	67.2	72.1 (7.1)	878	61	72.2 (7.8)
EADI longitudinal study	387	61.8	81.3 (5.6)	5416	61.1	79.3 (5.3)
CHARGE FHS	229	65.5	85.7 (6.3)	1979	54.1	80.7 (7.5)
CHARGE CHS	374	69.2	82.2 (5.0)	1675	60.6	81.1 (5.2)
CHARGE Rotterdam	764	73.2	83.1 (6.6)	4988	57.8	81.4 (6.9)
Total	14406	61.7	74.8	25849	59.6	79.0

b
SNP	Major/minor Alleles	MAF	CHRa	BP	Closest Gene	Logistic ORb	Logistic P value	Survival HR (95% CI)c	Survival P value	Heterogeneity P value
Previously reported associated loci
rs2093761	G/A	0.2019	1	207786542	CR1	1.16 (1.12–1.20)	2.6×10−14	1.07 (1.04–1.10)	1.2×10−6	0.25
rs6431219	C/T	0.4163	2	127862133	BIN1	1.12 (1.09–1.15)	7.6×10−13	1.08 (1.06–1.10)	3.9×10−10	0.16
rs1057233	A/G	0.3194	11	47376448	SPI1/CELF1d	0.93 (0.89–0.96)	5.4×10−6	0.94 (0.91–.97)	8.4×10−6	0.86
rs7930318	T/C	0.4004	11	60033371	MS4A	0.90 (0.87–0.93)	5.1×10−11	0.93 (0.90–.95)	2.3×10−9	0.6
rs567075	C/T	0.3097	11	85830157	PICALM	0.88 (0.85–0.91)	4.3×10−14	0.91 (0.89–.94)	9.1×10−12	0.74
rs9665907	G/A	0.1133	11	121435470	SORL1	0.88 (0.83–0.93)	1.8×10−7	0.92 (0.88–.95)	5.5×10−6	0.96
rs17125944	T/C	0.0924	14	53400629	FERMT2	1.13 (1.08–1.18)	1.0×10−5	1.10 (1.06–1.14)	2.3×10−6	0.31
rs4803758	G/T	0.3551	19	45327423	APOEe	1.33 (1.30–1.37)	1.2×10−67	1.21 (1.18–1.23)	7.8×10−52	0.32
Novel loci reaching suggestive significance
rs10919252	C/G	0.3275	1	169802956	C1orf112	1.04 (1.01–1.08)	1.1×10−2	1.10 (1.06–1.14)	8.2×10−7	0.92
rs1532244	A/G	0.0925	3	28057905	CMC1	0.95 (0.90–1.01)	6.9×10−2	0.86 (0.80–.93)	9.7×10−6	0.99
rs116341973	A/G	0.0227	3	63462893	SYNPR	1.20 (1.09–1.30)	5.4×10−4	1.23 (1.15–1.31)	2.5×10−7	0.62
rs71602496	A/G	0.1453	4	661002	PDE6B	1.02 (0.98–1.06)	3.6×10−1	1.08 (1.05–1.11)	5.0×10−6	0.11
rs1689013	T/C	0.2493	4	181048651	LINC00290	1.02 (0.98–1.06)	2.7×10−1	1.07 (1.04–1.09)	4.7×10−6	0.31
rs7445192	A/G	0.461	5	140138701	PCDHA1	NA	NA	1.06 (1.03–1.08)	7.9×10−6	0.77
rs12207208	T/C	0.1034	6	40301379	LINC00951	1.07 (1.02–1.20)	1.2×10−2	1.09 (1.05–1.13)	6.8×10−6	0.78
rs17170228	G/A	0.0623	7	33076314	NT5C3A	1.07 (1.01–1.14)	2.5×10−2	1.13 (1.08–1.18)	1.0×10−6	0.94
rs2725066	A/T	0.4872	8	4438058	CSMD1	1.03 (1.00–1.06)	7.3×10−2	1.10 (1.06–1.14)	1.0×10−6	0.6
rs7867518	T/C	0.476	9	2527525	VLDLR	0.97 (0.94–1.00)	6.8×10−2	0.95 (0.92–.97)	9.1×10−6	0.79
rs1625716	T/G	0.0643	10	59960083	IPMK	0.87 (0.80–0.94)	1.0×10−4	0.88 (0.82–.94)	7.7×10−6	0.95
rs1118069	T/A	0.2805	12	84739181	SLC6A15	0.98 (0.94–1.01)	2.0×10−1	0.90 (0.86–.95)	2.7×10−6	0.8
rs11074412	A/G	0.2087	16	19833001	IQCK	0.94 (0.90–0.98)	1.9×10−3	0.93 (0.90–.96)	7.0×10−6	0.48
rs5750677	C/T	0.2885	22	39147715	SUN2	0.97 (0.93–1.00)	5.1×10−2	0.94 (0.91–.97)	5.2×10−6	0.51

^aBuild 37, assembly hg19.

^bSummary statistics of the logistic regression were obtained from stage 1 of the IGAP GWAS.

^cCalculated with respect to the minor allele.

^dSPI1 is the nearest gene to rs1057233. The same locus was previously labeled as CELF1 in the 2013 IGAP GWAS paper¹.

^eThe nearest gene to rs4803758 is APOE.