Table 3. Significant cis-eQTL associations of the 22 suggestive and significant AAOS-associated SNPs.

Significance threshold is determined to be 2.52×10⁻⁶ based on Bonferroni correction for multiple testing. The minor alleles are considered as the effective allele.

SNPID	CHR	Probe_Id	Gene	Monocyte		Macrophage
				P value	Beta	P value	Beta
rs10919252	1	ILMN_1724422	SELL	7.33×10−35	−0.65	–	–
rs71602496	4	ILMN_1769751	PIGG	5.19×10−10	−0.46	9.11×10−13	−0.58
rs1625716	10	ILMN_2122953	CISD1	5.98×10−23	−1.09	7.82×10−8	−0.67
rs1057233	11	ILMN_1696463	SPI1	1.50×10−105	−1.11	6.41×10−87	−1.11
rs1057233	11	ILMN_1781184	MYBPC3	4.99×10−51	−0.83	5.58×10−23	−0.62
rs1057233	11	ILMN_1686516	CELF1	3.95×10−8	0.32	–	–
rs1057233	11	ILMN_2382083	CELF1	1.13×10−7	0.31	1.31×10−4	0.25
rs1057233	11	ILMN_1652989	NUP160	1.42×10−5	−0.26	5.35×10−22	−0.62
rs7930318	11	ILMN_2370336	MS4A4A	8.20×10−28	−0.56	–	–
rs7930318	11	ILMN_1721035	MS4A6A	4.90×10−23	−0.52	1.25×10−9	−0.35
rs7930318	11	ILMN_1741712	MS4A4A	1.48×10−11	−0.36	1.54×10−4	−0.22
rs7930318	11	ILMN_2359800	MS4A6A	1.94×10−10	−0.34	3.77×10−9	−0.34
rs11074412	16	ILMN_1783712	LOC400506	6.49×10−17	0.54	–	–
rs11074412	16	ILMN_2081883	IQCK	–	–	1.22×10−12	−0.52
rs4803758	19	ILMN_2337336	PVRL2	1.52×10−8	0.30	–	–
rs5750677	22	ILMN_2099301	SUN2	3.66×10−58	−0.90	3.15×10−36	−0.80
rs5750677	22	ILMN_1730879	CBY1	1.80×10−9	−0.37	–	–