Skip to main content
. Author manuscript; available in PMC: 2018 Jan 9.
Published in final edited form as: J Comp Neurol. 2015 Jul 21;523(17):2477–2494. doi: 10.1002/cne.23848

Figure 5.

Figure 5

NMJs are affected in early symptomatic SOD1G93A but not TDP43A315T mice. NMJs were examined in 90-day-old male control (A1) and SOD1G93A (B1) mice expressing YFP (A–B). AChR clusters (red) were labeled with fBTX (A1–B1). NMJs of male control (C1) and TDP43A315T (D1) mice were also examined at 90 days of age by labeling the presynapse with synaptotagmin (C–D). NMJs are spared in TDP43A315T (C–D1,E) but affected in SOD1G93A mice (A–B1,E). At least 50 NMJs were counted per mouse, and five animals were examined per group. Error bar = STE. ***P < 0.001. Scale bars = 20 μm in B1 (applies to A–B1), 20 μm in D1 (applies to C–D1).