Table 3.

Number of exacerbations and severe exacerbations per year, change in FEV₁, dyspnoea scores and distance covered in 6 min walk test from phase 1 to phase 2 visit (5-year interval)

	All (n=8479)	PREO-POSTO (n=3619)	PREN-POSTN (n=3936)	PREO-POSTN (n=636)	PREN-POSTO (n=288)	P value*
Exacerbations per year±SD	0.42±0.99	0.68±1.22	0.21±0.70	0.27±0.74	0.26±0.79	0.3
Severe exacerbations per year±SD	0.14±0.52	0.24±0.66	0.07±0.34	0.1±0.5	0.09±0.3	0.069

	All (n=4857)	PREO-POSTO (n=1889)	PREN-POSTN (n=2421)	PREO-POSTN (n=379)	PREN-POSTO (n=168)	P value*
Change in FEV1, mL±SD	−198.1±294.5	−202.5±320.2	−198.8±268.5	−203.6±282.2	−125.6±365.5	<0.001
Change in MMRC ±SD	0.06±1.24	0.19±1.26	−0.04±1.22	0.03±1.08	0.05±1.36	0.42
Change in SGRQ ±SD	0.15±15.3	1.5±15.2	−0.8±15.4	−0.88±14.6	0.98±16	0.86
Change in 6-MWD, feet±SD	−130.9±360.6	−172.7±366.4	−103.7±357	−103±327.4	−123.5±377	<0.001

*Comparison between PREO-POSTN and PREN-POSTO using χ² and Student’s t-test or Wilcoxon rank sum test.

6-6-MWD = 6-min walk distance; MMRC, modified Medical Research Council dyspnoea score; SGRQ, St. George’s Respiratory Questionnaire score.

PREN-POSTN: prebronchodilator FEV₁/FVC >0.7 and postbronchodilator FEV₁/FVC >0.7.

PREO-POSTNO: prebronchodilator FEV₁/FVC <0.7 and postbronchodilator FEV₁/FVC <0.7.

PREO-POSTN: prebronchodilator FEV₁/FVC <0.7 and postbronchodilator FEV₁/FVC >0.7.

PREN-POSTO: prebronchodilator FEV₁/FVC >0.7 and postbronchodilator FEV₁/FVC <0.7.