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Concept diagram showing the metabolic fate of hydroxytyrosol (DOPET) after olive ingestion. DOPET is broken down by at least four enzymes—monoamine‐preferring sulfotransferase (mPST), glucuronidase, catechol‐O‐methyltransferase (COMT), and alcohol dehydrogenase (AD). ALDH = aldehyde dehydrogenase; HVA = homovanillic acid; OMe‐DOPET = O‐methyl‐DOPET. We predicted relatively small increases in plasma DOPET because of a substantial first‐pass effect.
