Table 1.
Regensburg registry and other published trials and registries including patients treated by the MitraClip system
| Regensburg | GRASP [17] | TRAMI [19] | MitraSWISS [18] | Pilot Registry [21]a | ACCESS-EU [20] | EVEREST-II [1] | |
|---|---|---|---|---|---|---|---|
| Year of publication | 2016 | 2016 | 2014 | 2014 | 2013 | 2011 | |
| Participants | 102 | 180 | 749 | 74 | 628 | 567 | 184 |
| Female [%] | 42.2 | 38.3 | 38.6 | 27 | 36.9 | 36.2 | 38 |
| Age [years] | 77.0 ± 5.8 | 71.6 ± 9.8 | 76 (10)b | 72 ± 12 | 74.2 ± 9.7 | 73.7 ± 9.6 | 67.3 ± 12.8 |
| MR grade III/IV [%] | 100 | – | 93.8 | 100 | 86.1c | 97.7 | 96 |
| DMR [%] | 28.4 | 18.3 | 27.8 | 38 | 22.8 | 20.6 | 74 |
| FMR [%] | 71.6 | 81.7 | 71.3 | 62 | 72.0 | 69.3 | 27 |
| NYHA III/IV [%] | 75.5 | 81.1 | 89 | – | 85.5 | 84.9 | 52 |
| EuroScore II | 5.1 ± 5.9 | 7.6 ± 6.4 | – | – | – | – | – |
| LogEuroScore [%] | 26.6 ± 18.0 | – | 20 (19)f | 21 ± 17 | 20.4 ± 16.7 | 23.0 ± 18.3 | – |
| Regurgitant orifice area [cm2] | 0.40 ± 0.18 | – | – | – | 0.43 ± 0.16 | – | 0.56 ± 0.38 |
Shown are mean and standard deviation or proportions (if not indicated otherwise)
aTranscatheter Valve Treatment Sentinel Pilot Registry, bmedian (IQR), csevere (graded as mild, moderate, severe). MR mitral regurgitation, DMR degenerative mitral regurgitation, FMR functional mitral regurgitation, NYHA New York Heart Association functional classification