Table 2.

Receiver-operating Characteristics for Current Major Depressive Episode using Different Thresholds of the Depression Subscale of the Hospital Anxiety and Depression Scale (HADS-D)

Thresholds	n (%)	Sensitivity, % (95% CI)	Specificity, % (95% CI)	PPV, % (95% CI)	NPV, % (95% CI)	Accuracy, % (95% CI)	AUC (95% CI)
All study participants, n = 1115
≥ 6	610 (55)	94 (89–96)	54 (51–57)	31 (27–35)	97 (96–99)	61 (58–64)	0.86 (0.83–0.88)
≥ 7	499 (45)	90 (84–93)	65 (62–68)	36 (32–40)	97 (95–98)	70 (67–72)
≥ 8	414 (37)	87 (81–91)	74 (71–77)	42 (38–47)	96 (95–98)	76 (74–79)
≥ 9	336 (30)	77 (71–83)	80 (77–83)	46 (41–52)	94 (92–96)	80 (77–82)
≥ 10	263 (24)	64 (57–71)	85 (83–88)	49 (43–55)	92 (89–93)	81 (79–84)
With Metabolic syndrome only (WHO definition), n = 384
≥ 6	252 (66)	97 (91–100)	45 (39–51)	37 (31–44)	98 (93–100)	58 (53–63)	0.83 (0.79–0.87)
≥ 7	215 (56)	94 (86–98)	57 (51–63)	42 (36–49)	96 (92–99)	66 (61–71)
≥ 8	194 (51)	94 (86–98)	64 (58–70)	47 (40–54)	97 (93–99)	72 (67–76)
≥ 9	161 (42)	87 (78–93)	73 (68–78)	52 (44–60)	94 (90–97)	77 (72–81)
≥ 10	128 (33)	69 (59–78)	79 (73–83)	52 (43–61)	88 (84–92)	88 (84–92)
Without Metabolic syndrome only (WHO definition), n = 731
≥ 6	358 (49)	90 (83–95)	58 (54–62)	26 (22–31)	97 (95–99)	63 (59–66)	0.86 (0.82–0.89)
≥ 7	284 (39)	86 (77–92)	69 (65–72)	31 (26–37)	97 (94–98)	71 (68–75)
≥ 8	220 (30)	81 (72–88)	78 (75–81)	38 (32–45)	96 (94–98)	79 (75–82)
≥ 9	175 (24)	68 (58–77)	83 (80–86)	41 (33–48)	94 (92–96)	81 (78–84)
≥ 10	135 (18)	60 (50–69)	88 (86–91)	46 (37–55)	93 (91–95)	84 (81–87)

PPV positive predictive value, NPV negative predictive value, AUC area under the receiver operating curve, CI confidence interval

Optimal thresholds in bold