Fig. 7.

Elevated chemokines and cytokines in the ipsilateral DRG of CCI mice were downregulated by WWL70 treatment. RNA isolated from DRG taken from mice 7 days post-CCI was subjected to qRT-PCR analysis. The increased expression of CCL2 (a), CCR2 (b), and TNF-α (c) was detected in the CCI vehicle group and significantly suppressed by WWL70 (10 mg/kg). (*p < 0.05 and **p < 0.01 CCI/WWL70 compared to CCI/vehicle) (mean ± S.E.M., n = 10/group). NGF expression level was significantly increased in CCI vehicle group and attenuated by WWL70 administration (d). *p < 0.05 (mean ± S.E.M., n = 10/group)