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. 2018 Jan 8;15:9. doi: 10.1186/s12974-017-1045-9

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — Treatment with WWL70 did not reduce the elevated levels of 2-AG and AA in CCI mouse sciatic nerve. Fresh sciatic nerve tissues from CCI mice 7 days after surgery were subjected to LS-MS/MS. The amount of 2-AG (a) and AA (b) was significantly increased in the vehicle group compared to the sham. (*p < 0.05; mean ± S.E.M., n = 7). WWL70 (10 mg/kg) treatment did not significantly reduce the increased production of 2-AG and AA elicited by CCI, although a slight reduction was observed for the latter