Figure 3.

Pooled-adjacent-violators algorithm response rates in females (open circles) and in males (filled circles).

Notes: The EC₅₀ values (83% CI) of the remifentanil Ce for preventing emergence cough following extubation were 2.60 (2.29–2.91) ng/mL in males and 1.67 (1.55–1.83) ng/mL in females. The EC₉₅ values (95% CI) of remifentanil Ce for preventing emergence cough following extubation were 3.41 (3.27–3.58) ng/mL in males and 2.30 (2.02–2.62) ng/mL in females. Both EC₅₀ and EC₉₅ were significantly lower in the female group than in the male group. EC₅₀ is defined as the effective concentration for preventing emergence cough following extubation in 50% of patients. EC₉₅ is defined as the effective concentration for preventing emergence cough following extubation in 95% of patients.

Abbreviations: Ce, effect-site concentration; CI, confidence interval.