Table S1.
Profile algorithm test panel markers
| Protein name | Gene | SNP marker | Associated neuropsychiatric disorders |
|---|---|---|---|
| Catechol-O-methyltransferase | COMT | rs4680 | Alcohol abuse1,2 |
| Methamphetamine abuse2 | |||
| Heroin dependence3,4 | |||
| Cocaine dependence5,6 | |||
| Anxiety7,8 | |||
| Depression9,10 | |||
| Dopamine beta-hydroxylase | DBH | rs1611115 | Cocaine addiction11,12 |
| ADHD13 | |||
| Methamphetamine abuse14 | |||
| Schizophrenia15 | |||
| Dopamine D1 receptor | DRD1 | rs4532 | Depression16 |
| Heroin addiction17 | |||
| Alcohol dependence17 | |||
| Ankyrin repeat and kinase domain containing 1/dopamine receptor D2 | ANKK1/DRD2 | rs1800497 | Alcohol and cocaine dependence18 |
| Heroin abuse4,17,19 | |||
| Dopamine D4 receptor | DRD4 | rs3758653 | Anxiety20,21 |
| Heroin abuse22–24 | |||
| Dopamine transporter SLC6A3 | DAT | rs27072 | Methamphetamine addiction25 |
| Gamma aminobutyric acid receptor A, gamma2 subunit | GABRG2 | rs211014 | Alcohol abuse26 |
| Heroin abuse27 | |||
| Methamphetamine abuse27 | |||
| Opioid receptor, kappa 1 | OPRK1 | rs1051660 | Mood disorders28 |
| Alcohol dependence29 | |||
| Methylenetetrahydrofolate reductase | MTHFR | rs1801133 | Bipolar disorder, depression30,31 |
| Opioid receptor, mu 1 | OPRM1 | rs1799971 | Heroin addiction32 |
| Opioid use disorder33 | |||
| Substance use disorder34,35 | |||
| Alcoholism29,36,37 | |||
| Serotonin receptor 2A | HTR2A | rs7997012 | Drug abuse1 |
| Depression38 | |||
| Phenotypic traits | Risk factors | ||
| Age | 16–45 years39,43 | ||
| Personal history | Mental health disorders1,40–42 | ||
| Depression48–50 | |||
| Alcoholism43,44 | |||
| Illicit drug use45,46 | |||
| Prescription drug abuse47 | |||
Abbreviations: ADHD, attention-deficit hyperactive disorder; SNP, single-nucleotide polymorphism.