Fig. 1.

Differentially expressed genes and confirmation on RNA level a. Hierarchal clustering of 16 differentially expressed genes between persistent oligoarticular JIA (PR, red) and extended-to-be samples (ETB, light blue) separates 10 of the 12 persistent from extended-to-be, clusters the extended-to-be together and separates extended-to-be from most of the persistent. b. Hierarchal clustering of the same 16 genes based on the expression patterns in PR (red), ETB (light blue), extended (E, dark blue), and polyarticular (poly, yellow). The PR samples cluster separately from the other three groups, which cluster together. c. qRT-PCR confirmation of 10 select genes. * p-value <0.05; ** p-value <0.01. MAMLD1 and RAB27B did not meet statistical significance for differential expression by PCR when comparing FLS RNA from persistent and extended—to-be (Ext-to-be) JIA