Table 1.
Demographics of participants included in the analysis
| Variable | Noncarriers | C9orf72 |
GRN |
MAPT |
p-value |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| Presymptomatic | Affected | Presymptomatic | Affected | Presymptomatic | Affected | All groups | At-risk groups (including noncarriers) | Affected groups | ||
| N | 144 | 40 | 25 | 65 | 12 | 23 | 10 | - | - | - |
| Age, mean (SD) | 48.7 (14.3) | 43.5 (10.5) | 65.2 (7.7) | 48.9 (10.7) | 63.2 (6.0) | 38.6 (9.0) | 57.2 (5.9) | <0.001 | <0.001 | 0.011 |
| %Female | 63 | 63 | 28 | 63 | 67 | 61 | 30 | 0.021 | 1.000 | 0.083 |
| EYO, mean (SD) | −10.5 (14.2) | −15.0 (12.5) | 5.8 (5.0) | −10.3 (11.3) | 1.4 (2.1) | −11.8 (10.3) | 5.9 (3.5) | <0.001 | 0.270 | 0.001 |
| Education, y | 13.8 (3.4) | 13.9 (3.0) | 13.1 (4.5) | 14.1 (3.1) | 10 (3.8) | 13.4 (3.4) | 12.2 (4.7) | 0.040 | 0.788 | 0.125 |
| Disease duration, y | N/A | N/A | 6.6 (4.8) | N/A | 2.5 (1.3) | N/A | 4.9 (5.3) | N/A | N/A | 0.010 |
| MMSE (max = 30) | 29.2 (1.3) | 29.2 (1.2) | 24.8 (4.2) | 29.1 (1.4) | 20.7 (6.2) | 29.4 (1.4) | 24.7 (4.9) | <0.001 | 0.359 | 0.139 |
Diagnoses in affected subjects: bvFTD 33 (18 C9orf72, 5 GRN, 10 MAPT), 3 FTD-ALS (all C9orf72), 7 nonfluent variant primary progressive aphasia (PPA) (2 C9orf72, 5, GRN), 1 semantic variant PPA (C9orf72), 1 corticobasal syndrome (GRN), 1 dementia - not otherwise specified (C9orf72).
Bold text indicates a statistically significant difference (p< 0.05) between groups.