Figure 5.

TSL-1 reduces tumor volume and increases caspase-3 in animal study. Nude mice were intraperitoneally injected with 1 million Saos-2 cells and then randomly divided into 3 groups: control (DDW only; n = 5), 1 g/kg TSL-1 group (n = 5), and 5 g/kg TSL-1 group (n = 5). Changes in body weight (A) and tumor volume (B) weekly and at the end of experiment showed the tumor images (B). Immunohistochemistry analysis of the xenografts at the fifth week showed cleaved caspase-3 (C). (Third lanes are magnified areas indicated by red line, and fourth lanes are magnified areas indicated by yellow line.) **P < .001.