Table 2.
Antitumorigenicity of Tian Xian Liquid (TXL) Exhibited as a Result of Interactions Among Different Fractions of TXL.a
| Fraction | Proliferative Effect |
Inhibition of Tumor size In Vivo (Chu et al., 2011) | Upregulation of p21 Protein In Vivo (Figure 6) | Downregulation of MMP-1 Protein In Vivo (Figure 6) | Downregulation of MDR-1 Protein In Vivo (Figure 6) | |
|---|---|---|---|---|---|---|
| HT-29 (IC50) (Figure 2) | Mouse Splenocytes at Concentration 5% (Figure 3) | |||||
| EA | − | − − | − | + | − | − − − |
| BU | − − − | + + + + | − − − | − | − − − | − − |
| WA | − − − − | − | − − − − | − − | − − | − |
| TXL | − − | + + | − | + + + + | − − − − | − − − − |
| Interaction | Mutual antagonism | Mutual suppression /mutual counteraction | Mutual antagonism | Mutual enhancement | Mutual accentuation/mutual enhancement | |
Abbreviations: EA, ethyl acetate fraction of TXL; BU, butanol fraction of TXL; WA, aqueous fraction of TXL; IC50, half-maximal inhibitory concentration.
a
+, + +, + + +, and + + + + indicate the relative enhancing effect exhibited by the respective fractions of TXL and the whole formula of TXL. −, − −, − − −, and − − − − indicate the relative inhibitory effect exhibited by the respective fractions of TXL and the whole formula of TXL.