Figure 2.
Effect of active hexose correlated compound (AHCC) on aromatase activity of letrozole: the KGN cell line, which has a relatively high aromatase activity, was used for in vitro estrone and 17β-estradiol enzyme immunoassays.18 Because the KGN cell line lacks 17α-hydroxylase, it secretes little or no androstenedione, 17β-estradiol, or estrone, making it a suitable experimental tool for aromatase assay. 17β-Estradiol and estrone were measured in picogram per milliliter concentrations and reported as the percentage change in concentrations in the presence of AHCC compared with the known aromatase inhibitor, letrozole. Data demonstrate that AHCC alone is a potential inducer of aromatase and potentially enhanced the inhibition activity of letrozole in converting androstedione to estrone.