Table 2.
Genes That Are Differentially Expressed (>2.5-fold, P< .05) and Involved in Promoting Cell Death in FKB-Treated HeLa Cells Compared With Untreated Controls.
| Gene Bank | Gene Symbol | Gene Name | Fold Change >2.5 |
|---|---|---|---|
| Proapoptosis | |||
| NM_002485 | NBN | nibrin | −3.44 |
| NM_002546 | TNFRSF11B | tumor necrosis factor receptor superfamily, member 11b | −3.01 |
| NM_001289072 | HELLS | helicase, lymphoid-specific | −2.58 |
| NM_182972 | IRF2 | interferon regulatory factor 2 | −2.52 |
| NM_004031 | IRF7 | interferon regulatory factor 7 | 2.54 |
| NM_005427 | TP73 | tumor protein p73 | 2.74 |
| NM_021127 | PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 2.76 |
| NM_005658 | TRAF1 | TNF receptor-associated factor 1 | 3.09 |
| NM_148965 | TNFRSF25 | tumor necrosis factor receptor superfamily, member 25 | 3.20 |
| NM_003806 | HRK | harakiri, BCL2 interacting protein | 3.22 |
| NM_020396 | BCL2L10 | BCL2-like 10 (apoptosis facilitator) | 3.38 |
| NM_015675 | GADD45B | growth arrest and DNA-damage-inducible, beta | 4.06 |
| NM_006705 | GADD45G | growth arrest and DNA-damage-inducible, gamma | 30.80 |
| Cell cycle arrest | |||
| NM_153255 | MCM9 | minichromosome maintenance complex component 9 | −5.06 |
| NM_057749 | CCNE2 | cyclin E2 | −4.78 |
| NM_004091 | E2F2 | E2F transcription factor 2 | −4.33 |
| NM_001527 | HDAC2 | histone deacetylase 2 | −4.31 |
| NM_001166419 | HDAC8 | histone deacetylase 8 | −3.09 |
| NM_006044 | HDAC6 | histone deacetylase 6 | −2.75 |
| NM_182751 | MCM10 | minichromosome maintenance complex component 10 | −2.74 |
| NM_002800 | PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | −2.68 |
| NM_006739 | MCM5 | minichromosome maintenance complex component 5 | −2.55 |
| NM_002915 | RFC3 | replication factor C (activator 1) 3, 38kDa | −2.55 |
| NM_022111 | CLSPN | claspin | −2.51 |
| NM_078467 | CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 4.43 |
| Pro-oxidation | |||
| NM_003039 | SLC2A5 | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 | −17.32 |
| NM_018057 | SLC6A15 | solute carrier family 6 (neutral amino acid transporter), member 15 | −8.53 |
| NM_005233 | EPHA3 | EPH receptor A3 | −6.42 |
| NM_020342 | SLC39A10 | solute carrier family 39 (zinc transporter), member 10 | −3.81 |
| NM_173815 | CES4A | carboxylesterase 4A | −3.60 |
| NM_005573 | LMNB1 | lamin B1 | −3.56 |
| NM_004495 | NRG1 | neuregulin 1 | −3.47 |
| NM_001135147 | SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | −3.03 |
| NM_001025195 | CES1 | carboxylesterase 1 | 2.91 |
| MAPK | |||
| NM_002758 | MAP2K6 | mitogen-activated protein kinase kinase 6 | −4.99 |
| NM_005739 | RASGRP1 | RAS guanyl releasing protein 1 (calcium and DAG-regulated) | −3.78 |
| NM_006609 | MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | −3.09 |
| NM_002007 | FGF4 | fibroblast growth factor 4 | −2.96 |
| NM_003239 | TGFB3 | transforming growth factor, beta 3 | −2.72 |
| NM_002738 | PRKCB | protein kinase C, beta | −2.71 |
| NM_002397 | MEF2C | myocyte enhancer factor 2C | −2.67 |
| NM_005228 | EGFR | epidermal growth factor receptor | −2.57 |
| NM_005207 | CRKL | v-crk avian sarcoma virus CT10 oncogene homolog-like | −2.55 |
| NM_004417 | DUSP1 | dual specificity phosphatase 1 | 3.24 |
| NR_002834 | DUSP5 | dual specificity phosphatase 5 | 3.79 |
| NM_001963 | EGF | epidermal growth factor | 5.20 |
| NM_004083 | DDIT3 | DNA-damage-inducible transcript 3 | 10.81 |