Table 2.
Adjusted hazard ratios (HR) and 95% confidence intervals (95% CI) for the association of the metabolic syndrome (MS) and its individual components with colorectal cancer in time-dependent covariates analyses in the Women’s Health Initiative
| Metabolic Syndrome | Colorectal cancer HR (95% CI)* |
Colon cancer HR (95% CI)* |
|---|---|---|
| 1–3 years** | (Ncases = 32) | (Ncases = 22) |
| No | 1.00 (ref.) | 1.00 (ref.) |
| Yes | 2.06 (0.93–4.54) | 1.76 (0.66–4.69) |
| 2–4 years** | (Ncases = 32) | (Ncases = 25) |
| No | 1.00 (ref.) | 1.00 (ref.) |
| Yes | 2.68 (1.23–5.83) | 2.30 (0.94–5.59) |
| 3–5 years** | (Ncases = 35) | (Ncases = 29) |
| No | 1.00 (ref.) | 1.00 (ref.) |
| Yes | 1.88 (0.89–3.99) | 2.02 (0.88–4.64) |
Adjusted for the following variables: age (continuous), ethnicity (white, black, other), body mass index (continuous), alcohol (servings per week – continuous), family history of colorectal cancer (yes/no), physical activity (METs per week - continuous), and participation in the OS vs. CT, and treatment arm in the clinical trials.
Most recent measurement within the time interval was used to predict presence of the metabolic syndrome.
Mutually adjusted for all other components of the metabolic syndrome in addition to covariates listed above.