Table 4. Top IPA networks sharing common hub genes.

Dataset	Network attributes	AMY		NAC		PFC
0hDEmiR/ 120hDEtargets	Rank	1	2	2	2	1	2
	Score	39	32	41	41	41	36
	# Focus Molecules/ # Dataset Molecules	21/47	21/47	21/87	21/87	23/197	21/197
8hDEmiR/ 120hDEtargets	Rank	1	1	1	2		1
	Score	43	43	45	39		41
	# Focus Molecules/ # Dataset Molecules	19/58	19/58	23/141	21/141		18/50
120hDEmiR/ 120hDEtargets	Rank		1	1		1
	Score		40	36		21
	# Focus Molecules/ # Dataset Molecules		17/41	18/87		11/28
	Shared Hub Genes	Smad3	Bcl2, Erk1/2	Erk1/2	NF-kB	Srf, Erk1/2	NF-kB

Paired datasets of 0, 8 or 120h DE microRNAs and their 120h DE targets were used in conjunction with IPA Knowledgebase molecules to generate highly connected networks. Each network contained 35 molecules. Statistical fit between each network and its source dataset was evaluated with a right tailed Fisher's exact test. Rank indicates relative statistical significance among all derived networks with the lowest rank (1) representing the most significant network. Network score is the -log₁₀ of Fisher's exact p value. Focus molecules are network molecules originating from the dataset. Hub genes were identified based on high connectivity in multiple networks derived from different datasets.