Table 1.

Criteria for definition of Late-Onset VOD (according to “The new classification from the European Society for Blood and Marrow Transplantation”, BMT 2016).⁶

Late Onset VOD (> 21 Days after HSCT)
Classical VOD/SOS beyond day 21: Bilirubin ≥ 2 mg/dL and two of the following criteria: Painful hepatomegaly OR weight gain > 5% OR ascites
OR  Histologically proven VOD/SOS
OR  Two or more of the following criteria: Bilirubin ≥ 2 mg/dL (or 34 micromols/L) OR Painful hepatomegaly OR weight gain > 5% OR ascites   moreover, hemodynamical or/and ultrasound evidence of VOD/SOS

Abbreviations: EBMT =European Society for Blood and Marrow Transplantation; SOS =sinusoidal obstruction syndrome; VOD =veno-occlusive disease. These symptoms/signs should not be attributable to other causes.