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. 2017 Dec 15;6:e28132. doi: 10.7554/eLife.28132

Figure 4. CS pause response reflecting CS-related Purkinje cell complex spike.

(A) Combined complex spike raster plot for 9 Purkinje cells ordered by the latency of their clear CS-related complex spike response in addition to the US-related complex spike (data from ten Brinke et al., 2015). (B) Combined raster plot for 7 IpN neurons, ordered by the latency of their CS pause in spike activity. (C) Same as in B, but for 12 of the 41 IpN neurons in the second dataset that showed a CS pause. (D-F) Average spike traces corresponding to the cells shown in (A-C), with (D) showing the probability of a complex spike instead of relative spike rate. (G) CS pause latency plotted against the latency at which the CR passes 5% eyelid closure, for all 45 cells showing both properties across the original and the second dataset. (H) Probability across days of finding a transient spike response at CS-complex spike latency, inhibitory (this figure) or excitatory (Figure 4—figure supplement 1), in the first dataset.

Figure 4.

Figure 4—figure supplement 1. Transient spike increase at CS-complex spike latency.

Figure 4—figure supplement 1.

(A) Raster plot showing IpN spikes during paired trials in 4 cells that show a blunted peak response around the CS-complex spike latency. (B) Average spike traces for the cells in A. (C) Minimum spike rate in the CS-US interval did not seem more or less pronounced in suppressive cells with this blunted peak (Pk, −33.6 ± 15.4 Hz) compared to those without (−34 ± 9.6 Hz, p=1, MWU). (D) Same as C, here showing no difference in spike rate velocity (−2.1 ± 1.4 vs −1.2 ± 0.7 Hz/ms, p=0.2096, MWU). (E) Same as C, here showing no difference in recording depth (2048 ± 181 vs 2120 ± 36 um, p=0.7348, MWU).